What are the genetic patterns of tyrosinemia?
All three forms of tyrosinemia are inherited in an autosomal recessive manner. The statistics on the frequency of tyrosinemia types II and III are a little unclear because they are very uncommon, but tyrosinemia type I affects roughly 1 in every 100,000 people around the globe. Therefore, roughly 1 in 316 people carry the allele.
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In order to model the change in frequencies of this allele in a population, I used a spreadsheet with charts. Because the model population is only 16 individuals per generation, none of them were affected.
The conditions of my model apply to regions that do not have access to adequate medical care for tyrosinemia, so all affected individuals are assumed not to survive to reproductive maturity. |
For the full version of the spreadsheet model, click here.